Single-Donor Fecal Transplant Trial for IBS Shows Lasting Response
Fecal microbiota transplantation (FMT) resulted in sustained high response rates in patients with irritable bowel syndrome (IBS) and resulted in only mild side effects after 3 years, new data show. Nearly three out of four people in a clinical trial experienced fewer symptoms and fatigue and a greater quality of life at both 2 years and 3 years after FMT, in Norway. Those FMT-treated patients who relapsed subsequently responded to FMT upon retransplantation, report the authors, who also correlated individual microbial profiles with clinical outcomes.
@preyashi The new study included 125 patients (104 women, 21 men) in three groups: 38 received a placebo, 42 received 30 g of donor feces, and 45 received 60 g of donor feces. The feces — all from one male donor — was administered to the duodenum. The response rates for those who received FMT were significantly higher than for those who received placebo. Those receiving 30 g of feces had a response rate of 69.1%, and those in the 60-g group had a response rate of 77.8%, whereas the response rate in the placebo group was 26.3%.