A Pill for C difficile Works by Increasing Microbiome Diversity
An oral treatment with freeze-dried human stool can successfully treat Clostridioides difficile infections by increasing the diversity of microorganisms in the colon, researchers say. CP101, under development by Finch Therapeutics, proved more effective than a placebo in preventing recurrent infections for up to 24 weeks. The CP101 capsules contain a powder of freeze-dried human stools from screened donors. They restore natural diversity that has been disrupted by antibiotics, said Jessica Allegretti, MD, MPH a gastroenterologist at Brigham and Women's Hospital in Boston, Massachusetts.
@bhumika The treatment offers an alternative to fecal microbiota transplant, which can effectively treat antibiotic-resistant C difficile infections but is difficult to standardize and administer — and doesn't have full approval from the US Food and Drug Administration