Common Genetic Disorder Tied to Increased Dementia Risk in Men
Men with iron overload due to hereditary hemochromatosis are at increased risk of developing dementia, an analysis of UK Biobank data indicates. Results of a large analysis showed that among men who had two mutations that cause hemochromatosis (HFE C282Y homozygotes), brain iron deposition was more marked in dementia-relevant areas, and they were significantly more likely to be diagnosed with dementia over a 10-year period than men who did not have these mutations.
@antara It is vital that patients with hereditary hemochromatosis are diagnosed and treated earlier. This is likely to prevent substantial excess morbidity, including from dementia but also from liver disease, liver cancer, diabetes, and osteoarthritis