Time-Restricted Eating Restores Gut Microbiome Rhythm (in Mice)
Time-restricted feeding restored a healthy gut microbiome that was lost with diet-induced obesity in a mouse study. The findings might help explain how time-restricted eating might prevent obesity and type 2 diabetes in people, Ana Carolina Dantas Machado, PhD, from University of California San Diego (UCSD), and colleagues suggest. The team compared changes in the ileal microbiome (the microbe composition in part of the small intestine) every 4 hours during a 24-hour period in three groups of mice.
@adrita Time-restricted feeding restored diurnal rhythms of ileal microbiome oscillations, bile acid signaling, GLP-1 signaling (which affects glucose metabolism), and circadian rhythms of transcription of protein-coding genes that were lost in mice with diet-induced obesity. Unlike other gut microbiome research, this study focused on the ileum rather than the large intestine or stool.