Metformin Linked With Less Dementia in People With Diabetes
In an observational study of more than 112,000 US residents aged 50 years or older with type 2 diabetes, new users of metformin had about a 20% lower rate of incident dementia compared to new users of sulfonylurea during 5 years of follow-up. The new users of metformin also had about a 20% lower rate of Alzheimer's disease (AD) and vascular dementia than new users of sulfonylurea, but they were not at lower risk of mild cognitive impairment (MCI) or Parkinson's disease (PD).
@maggie Type 2 diabetes is a well-established risk factor for dementia and PD, suggesting that metformin might reduce the risk of these neurodegenerative diseases, but findings from prior studies have been inconsistent, and these studies also had important limitations. The authors said that this is the largest observational study to investigate the association between metformin and multiple neurodegenerative outcomes, that it used a variety of statistical methods to reduce bias and to validate the robustness of the results, and that it provides stronger evidence of the potential neuroprotective qualities of metformin regarding risk of dementia.