Vitamin D Fails to Prevent Late-Life Depression, Boost Mood
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Findings from a large randomized controlled trial do not support the use of vitamin D3 supplementation for adults for the sole purpose of preventing depression. Among adults aged 50 years or older who were without clinically relevant depressive symptoms at baseline, vitamin D3 supplementation taken over 5 years did not reduce the risk for depression or make a difference in the quality of mood.
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@miraj The risk for depression or clinically relevant depressive symptoms (total of incident and recurrent cases) was not significantly different between the vitamin D3 group (609 depression or clinically relevant depressive symptom events; 12.9/1000 person-years) and the placebo group (625 depression or clinically relevant depressive symptom events; 13.3/1000 person-years). The hazard ratio was 0.97 (95% CI, 0.87 – 1.09; P = .62).