Mild Cognitive Impairment- what is the pathology?
In mild cognitive impairment (MCI), the changes in cognition exceeds the normal, expected changes related to age. In one classification of MCI, the amnestic form is distinguished from the nonamnestic form. The amnestic form often precedes Alzheimer disease.
@sushmita The pathophysiology of MCI is multifactorial. Most cases of amnestic MCI result from pathologic changes of AD that have not yet become severe enough to cause clinical dementia. At least in specialty research populations, autopsies done on amnestic MCI patients have found the neuropathology to be typical of AD. Nonamnestic MCI may be associated with cerebrovascular disease, frontotemporal dementias (as a precursor), or no specific pathology.