Vitamins or Cocoa: Which Preserves Cognition?
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Unexpected results from a phase 3 trial exploring the effect of multivitamins and cognition have now been published. Findings from a phase 3 study show daily multivitamin use, but not cocoa, is linked to a significantly slower rate of age-related cognitive decline. Originally presented last November at the 14th Clinical Trials on Alzheimer's Disease (CTAD) conference and reported by Medscape Medical News at that time, this is the first large-scale, long-term randomized controlled trial to examine the effects of cocoa extract and multivitamins on global cognition. The trial's primary focus was on cocoa extract, which earlier studies suggest may preserve cognitive function. Analyzing the effect of multivitamins was a secondary outcome.
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@kirti Results showed cocoa extract had no effect on global cognition compared with placebo (mean z-score, 0.03; P = .28). Daily multivitamin use, however, did show significant benefits on global cognition vs placebo (mean z, 0.07, P = .007).