Unique Transcriptional Coronary Endothelial Cell Pattern in COVID

[dovie]

SARS-CoV-2 myocarditis is predominantly associated with capillaritis, and tissues directly infected with SARS-CoV-2 have unique, pro-inflammatory expression profiles as measured by spatial transcriptomic profiling. Unique regional and viral dependent differences within the myocardium and capillary bed may influence the risk for cardiovascular events associated with SARS-CoV-2 infection.

[Finaaz]

@dovie This is the first study to demonstrate that altered myocardial programming during severe COVID-19 is associated with capillary endothelial cells and not larger coronary vessels, suggesting that endotheliitis and endothelial activation are not likely key drivers of cardiovascular events during severe COVID-19.