Is Brain Insulin Important for Whole-Body Metabolism?
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Data from animal models showed that animals who didn't have any insulin in their brain developed a type 2 diabetes–like phenotype. We wondered if this is true in humans. Can it be that insulin acts in the human brain? Is this important for metabolism in the entire body? This is how I became interested in studying how insulin acts in the human brain. What we've learned so far is that, indeed, insulin acts in the human brain. This happens in many persons, but there's a substantial number of persons who are insulin resistant in their brain. In these individuals, the brain no longer responds to insulin.
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@inshita If insulin action in the brain is good, your body stores energy in the subcutaneous compartment. In the case of brain insulin resistance, these processes are disturbed. The brain can't control peripheral metabolism, and in the long run, this leads to an accumulation of visceral fat.