Diuretic Agents Equal to Prevent CV Events in Hypertension: DCP

[Rajab]

There was no difference in major cardiovascular outcomes with the use of two different diuretics — chlorthalidone or hydrochlorothiazide — in the treatment of hypertension in a new large randomized real-world study.

The Diuretic Comparison Project (DCP), which was conducted in more than 13,500 U.S. veterans age 65 years or over, showed almost identical rates of the primary composite endpoint, including myocardial infarction (MI), stroke, noncancer death, hospitalization for acute heart failure, or urgent revascularization, after a median of 2.4 years of follow-up.

There was also no difference in any of the individual endpoints or other secondary cardiovascular outcomes.

[Debra]

@rajab However, in the subgroup of patients who had a history of MI or stroke (who made up about 10% of the study population), there was a significant reduction in the primary endpoint with chlorthalidone, whereas those without a history of MI or stroke appeared to have an increased risk for primary outcome events while receiving chlorthalidone compared with those receiving hydrochlorothiazide.