What is the role of pregabalin in reducing pain?
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Hello, my grandmother is 78 years old. She is suffering from chronic pain. Doctor has diagnosed this pain as neuropathic pain. She has been prescribed pregabalin. After taking that she is feeling good. There is lot of improvement in her health. I want to know how this medicine works. I am studying in class 12. I would like to become a doctor. So I am interested in learning medicines. Please can somebody provide some information on pregabalin.
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@bidhan Pregabalin is an antagonist of voltage gated Ca2+ channels and specifically binds to alpha-2-delta subunit to produce antiepileptic and analgesic actions. It successfully alleviates the symptoms of various types of neuropathic pain and presents itself as a first line therapeutic agent with remarkable safety and efficacy. Preclinical studies in various animal models of neuropathic pain have shown its effectiveness in treating the symptoms like allodynia and hyperalgesia. Clinical studies in different age groups and in different types of neuropathic pain (peripheral diabetic neuropathy, fibromyalgia, post-herpetic neuralgia, cancer chemotherapy-induced neuropathic pain) have projected it as the most effective agent either as monotherapy or in combined regimens in terms of cost effectiveness, tolerability and overall improvement in neuropathic pain states.